[Sofia, Bulgaria] – Comac Medical is pleased to announce the publication of a new scientific article, co-authored by Professor Krassimir Kalinov, Head of the Statistics Team at Comac Medical.
Recently published in the Journal of Clinical Medicine, a peer-reviewed journal, the study, titled “Prevalence of Various Systemic and Organ-Specific Autoimmune Markers in Addison’s Disease Patients Compared to Healthy Controls,” offers valuable insights into the broader immunological profile of patients living with Addison’s disease.
Addison’s disease is a rare endocrine disorder that affects the adrenal glands, often arising in the context of autoimmune dysfunction. While it is well known that Addison’s disease can occur alongside other autoimmune conditions, the presence of specific systemic immune markers in these patients has not been thoroughly investigated until now.
This study examined a cohort of adult Addison’s disease patients and healthy controls, comparing levels of various autoantibodies which are proteins produced by the immune system that mistakenly target the body’s own tissues. Two markers in particular were found to be significantly more prevalent in Addison’s disease patients:
✔️Rheumatoid factor (RF), commonly associated with autoimmune arthritis
✔️Antinuclear antibodies (ANA), often present in autoimmune conditions such as lupus
The presence of these markers suggests that Addison’s disease may frequently co-occur with, or predispose patients to, additional autoimmune responses beyond the adrenal glands. Furthermore, a positive correlation was observed between RF and 21-hydroxylase antibodies, which are diagnostic markers for Addison’s disease, indicating a possible shared immunological mechanism.
These findings underscore the importance of comprehensive autoimmune screening and long-term monitoring in Addison’s disease patients. The study also calls for further research across diverse populations to determine the broader clinical significance of these markers and to inform tailored follow-up protocols.
This publication reflects Comac Medical’s continued commitment to advancing scientific research that deepens understanding of complex diseases and informs better clinical care. Through consistent and active contributions to academic literature, Comac Medical supports the development of data-driven, patient-centered approaches in drug development and disease management.
Click here to read the full publication.
About Comac Medical
Comac Medical has a proven track record and extensive operational and scientific expertise across a range of related therapeutic areas, including nephrology, rheumatology, immunology, and endocrinology. To learn more about our experience in these areas, view our therapeutic areas overview here.
